During the transit process of engineered B cells to plasma cells, a profound metabolic alteration occurs to accommodate lineage changes to protein-secreting cells. There is not abundant knowledge on the differentiation program, and it is necessary to evaluate the engineered cell products by monitoring the metabolic state of cells during differentiation. Metabolomics allows the global...
Engineered B cells should be induced to differentiate into plasma cells and become long-lived, protein-secreting cells to perform potential oncology therapeutic functions. When B cells bind antigens in vivo, this complex B cell differentiation process involves proliferation, isotype switching, affinity maturation, and terminal differentiation. As a profound metamorphosis of the genome to...
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